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An emphasis on nature can seem reductionistic and determinist, while a focus on nurture may be seen as humanistic and hopeful Some opposition has come from clinicians who fear that genetic theories deny patients the capacity to change (Paris, 1999, 2000b) Psychoanalysts (Hale, 1995) and behaviorists (Skinner, 1957), although they disagree about many things, both subscribe to theories in which psychopathology is seen as a product of life experience In psychiatry, critics of contemporary practice (eg, Luhrmann, 2000) have expressed concern that physicians who base interventions exclusively on biology lose empathy for the suffering of patients Intellectual issues also underlie opposition to theories in which human behavior is shaped by nature Many have been concerned about the political and ideological implications of biological models (Pinker, 2002) In particular, Marxist biologists (eg, Lewontin, Rose, & Kamin, 1985) have opposed the concept of a fixed human nature.

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Tenacious opposition to genetic or biological explanations of behavior has also come from sociologists and anthropologists who espouse various forms of cultural relativism (Degler, 1991) Finally, developmental psychology has been dominated by an almost exclusive focus on environmental factors (Harris, 1998) In recent years, the Zeitgeist has been changing, and the pendulum has swung away from nurture and toward nature Recent advances in behavioral genetics (Plomin, DeFries, McClearn, & Rutter, 2001) conclusively show that biology is a major determinant of individual differences in human psychology, and future research may discover links to.

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pressure and hypertension incidence in overweight people with high-normal blood pressure: The Trials of Hypertension, Phase II Archives of Internal Medicine, 157, 657 667 Tunstall-Pedoe, H (2000) Estimation of contribution of changes in coronary care to improving survival, event rates, and coronary heart disease mortality across the WHO MONICA Project populations Lancet, 355, 688 700 Verrier, R L, & Mittleman, M A (1996) Life-threatening cardiovascular consequences of anger in patients with coronary heart disease Cardiology Clinics, 14, 289 307 Vogt, T, Pope, C, Mullooly, J, & Hollis, J (1994) Mental health status as a predictor of morbidity and mortality: A 15-year follow-up of members of a health maintenance organization American Journal of Public Health, 84, 227 231 Ward, R (1990) Familial aggregation and genetic epidemiology of blood pressure In J H Laragh & B M Brenner (Eds), Hypertension pathophysiology, diagnosis and management (pp 81 100).

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TABLE 6.5 Effects of Strategies Designed to Improve Long-Term Outcome Bene cial Effect Observed Bene cial Effect Strategy Very-low calorie diets Continued therapy Extended therapy (continued weekly or biweekly group sessions up to one year) Therapist contact by mail phone Telephone prompts by nontherapists Skills training Relapse prevention training during initial treatment Relapse prevention training combined with posttreatment therapist contacts Portion-controlled meals Provision of portion-controlled meals Optional purchase of portion-controlled meals Financial incentives Financial incentives for weight loss Financial incentives for exercise Physical activity Supervised exercise Use of personal trainers Home-based exercise Short-bout exercise home exercise equipment Social support training Peer support training Social support training for clients recruited with friends or relatives Multicomponent programs Therapist contact increased exercise Therapist contact social support Therapist contact increased exercise social support Source: Data from Perri (2002). 6 to 12 Months after Initial Treatment Yes Bene cial Effect 13 or More Months after Initial Treatment No

= 90.63, d f = 84, p = .22 .12 .21 .75 .17 .49 .56 .46 .50 .33 .49 .33 .23 .49 .45 .52 .59

New York: Raven Press Wassertheil-Smoller, S, Applegate, W B, Berge, K, Chang, C J, Davis, B R, Grimm, R, et al (1996) Change in depression as a precursor of cardiovascular events Archives of Internal Medicine, 156, 553 561 Weder, A B, & Julius, S (1985) Behavior, blood pressure variability and hypertension Psychosomatic Medicine, 47, 406 414 Weinberger, M H (1996) Salt sensitivity of blood pressure in human Hypertension, 27, 487 490 Weiner, H, & Sapira, J D (1987) Hypertension: A challenge to behavioral research In S Julius & D R Bassett (Eds), Handbook of hypertension: Behavioral factors in hypertension (Vol 9, pp 59 74) Amsterdam: Elsevier Wells, J A (1985) Chronic life situations and life change events In A M Ostfeld & E D Eaker (Eds), Measuring psychosocial variables in epidemiologic studies of cardiovascular disease (NIH Publication No 85 2270).

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