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For diseases of this type, Gowers in 1902 suggested the term abiotrophy, by which he meant a lack of vital endurance of the affected neurons, resulting in their premature death This concept embodies an untested, unproven hypothesis that aging and degenerative changes of cells are based on the same process Understandably, contemporary neuropathologists are reluctant to attribute to simple aging the diverse processes of cellular diseases that are constantly being revealed by ultrastructural and molecular genetic techniques The reader may be perplexed by the inconsistent use of the terms atrophy and degeneration, both of which are applied to diseases of this category Spatz argued that on purely histopathologic grounds they are different Atrophy speci es a gradual wasting and loss of a system of neurons, leaving in their wake no degradative products and only a sparsely cellular, brous gliosis.

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Degeneration refers to a more rapid process of neuronal, myelin, or tissue breakdown, the degradative products of which evoke a more vigorous reaction of phagocytosis and cellular astrogliosis The difference lies in both the speed and the type of breakdown It is of some interest that many of the diseases characterized by degeneration, in Spatz s sense of the term, are now known to be of metabolic origin, while very few of the purely atrophic ones have been shown to have a metabolic basis There are also, within recent memory, several examples of diseases that were formerly classed as degenerative but are now known to have a metabolic, toxic, or nutritional basis or to be caused by a slow virus or a nonviral transmissible agent It seems reasonable to expect that with increasing knowledge, more and more diseases whose causes are now unknown will nd their way into these categories.

We will now work in the opposite direction factoring. First we will factor quadratic polynomials, expressions of the form ax2 bx c (where a is not 0). For example x2 5x 6 is factored as x 2 x 3 . Quadratic polynomials whose rst factors are x2 are the easiest to factor. Their factorization always begins as x x . This forces the rst factor to be x2 when the FOIL method is used All you need to do is ll in the two blanks and decide when to use plus and minus signs. All quadratic polynomials factor though some do not factor nicely. We will only concern ourselves with nicely factorable polynomials in this chapter. If the second sign is minus, then the signs in the factors will be di erent (one plus and one minus). If the second sign is plus then both of the signs will be the same. In this case, if the rst sign in the trinomial is a plus sign, both signs in the factors will be plus; and if the rst sign in the trinomial is a minus sign, both signs in the factors will be minus.

Major events Formation of Earth Primordial soup Stromatolites containing bacteria Unicellular prokaryotes, then eukaryotes Multicellular eukaryote organisms (algae) appear Ancient Life Era First vertebrates ( sh), land animals (amphibians, reptiles), land plants, fungi, insects Middle Life Era, Age of Reptiles Flying reptiles become birds Small mammals and owering plants appear Rise and fall of the dinosaurs New Life Era, Age of Mammals Modern mammals and birds evolve from reptiles Primates (monkeys, apes, apelike human ancestors) The Ice Age, including arrival of Homo sapiens

As was pointed out in Chap 29, on aging, more than half of the normal life cycle of the organism involves a slow deterioration of organ function Such changes in the nervous system are manifest in every sensory and motor system and in all cerebral functions The basis of these aging changes is theoretically at the neuronal level, but it is not fully understood A fundamental problem is the distinction of these aging deteriorations from degenerative disease When the latter appears in adult life, one must assume that the clinical presentation is modi ed to some extent by life-cycle phenomena the patient s function being a gestalt of both processes 895.

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BRIEF HISTORY OF THE VL4%

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