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Furthermore, it is inconceivable that risk assessments of EDCs could be conducted solely with in vitro data, due to the need to account for route of exposure, rate of uptake, transfer to the site of toxic action, metabolism and excretion This does not, of course, mean that in vitro tests have no part to play in hazard assessment schemes for EDCs, but at the present state of knowledge they will have to take a secondary role, being used primarily to assist interpretation of modes of action, etc At present, there are no internationally agreed in vivo sh tests which are suitable for assessing the hazards of EDCs, although several (eg OECD, 1992, 1999) have end-points such as hatching success and growth rate which could well be interfered with via endocrine processes (but also by non-endocrine routes).

literature that patent mapping may be used to highlight various features of a patent portfolio. Thus, for example, the number of patents issued in the name of various inventors may be graphed. The idea here is that the high points on the graph identify the most prolific inventors (well, duh!). It has even been suggested that this analysis be refined to identify the number of patents whose inventors are no longer employed by the patentee organization (inventor employment analysis). It is implied that having many inventors leave an organization is not a good thing (again well, duh!). Similarly, one may graph numbers of patents against patent age. This is intended to provide an indication of portfolio aging and warn of impending expiration or technological obsolescence.

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[1] Digital cellular telecommunications system (phase 2); security aspects (GSM 02.09 version 4.5.1), ETS 300 506. [2] Digital cellular telecommunications system (phase 2); security related network functions (GSM 03.20 version 4.4.1), ETS 300 534. [3] Biryukov A., Shamir A. Real time cryptanalysis of the alleged A5/1 on a PC, preliminary draft, December 1999. [4] Golic J.Dj. Cryptanalysis of alleged A5 stream cipher. Eurocrypt 97, published as lecture notes in Computer science #1233, Springer Verlag, Berlin, 1997.

The Organisation of Economic Co-operation and Development (OECD) has recognised this gap, and it convened an OECD Expert Consultation on the issue in October 1998 (OECD, 1999) This meeting accepted the need for both sh-based screening procedures (which would provide information about a chemical s basic endocrine disrupting properties), and sh testing proper, the latter being suitable for environmental risk assessments In the rst case, the objective is to inform priorities for testing and to throw light on mechanisms of action, whereas the latter procedures will fully characterise the effects to be expected under realistic exposure scenarios The Expert Consultation concentrated on three major types of endocrine disruption: oestrogenic/anti-oestrogenic effects, androgenic/anti-androgenic effects, and thyroid hormone interference, although in practice most progress was made with the rst two categories The meeting agreed on a tiered sh testing approach for these EDCs (Table 52), as follows.

One s trust in a company is often based entirely on our assessment of their competence, measured by observing how they treat our current transaction. So it is worth remembering that an on-line store is only as good as it behaves: broken links, messages of the JaveScript error at line xxx are interpreted by the potential customer, probably correctly, as a sign of how well resourced and managed is the on-line operation. The only real way to make sure that the quality of a company s brand is not tarnished is by testing, testing, testing, not just on the desk, but also in the eld using naIve as well as expert users. Different browsers throw up different problems, as do different default colour and font settings. Back buttons and other hot links that are easy to see on a developer s large monitor may be off the screen of a smaller monitor. Consider how your site will look when accessed at the end of a slow link as well as from the company s LAN. Code walk-throughs are standard practice in good software companies, but far too few do eld testing of user interfaces. Probably it should be the responsibility of non-software-oriented people, perhaps a bunch of loyal customers can be recruited instead. Finally, as research on the subject has con rmed [77], trust is more easily lost than re-gained. One bad experience with an on-line nancial transaction may be all that potential customers need to avoid your site in the future. Thus, although we emphasise that it is trust that is the issue, it is now time to look at the single most powerful way that this trust can be gained: the issue of security.

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