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Cytogeneticists have divided the prophase of meiosis I into ve stages: leptonema, zygonema, pachynema, diplonema, and diakinesis (Greek: lepto-, thin; zygo-, yoke-shaped; pachy-, thick; diplo-, double; dia-, across). A cell entering prophase I (leptotene stage) behaves similarly to one entering prophase of mitosis, with the centrosome duplicated and the spindle forming around the intact nucleus. (Note the adjectival forms leptotene versus the noun forms leptonema of the stage names.) As the chromosomes coil down in size during leptonema, they are visible as individual threads: sister chromatids are in such close apposition that they are not distinct. The chromosomes are more spread out than they are in mitosis, with dark spheres or bands called chromomeres interspersed. The tips of the chromosomes are attached to the nuclear membrane in the leptotene stage ( g. 3.19). In the leptotene to zygotene transition, the tips of the chromosomes move until most end up in a limited region near each other. This forms an arrangement called a bouquet stage. Presumably, this arrangement helps homologous chromosomes nd each other and begin the pairing process without becoming entangled. The pairing of homologous chromosomes marks the zygotene stage. Initial contact between identical regions of homologous chromosomes leads to a point-for-point pairing along their lengths. This process is referred to as synapsis. A proteinaceous complex, referred to as a

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R1 = 802

Selection experiments are done for several reasons Plant and animal breeders select the most desirable individuals as parents in order to improve their stock Population geneticists select speci c characteristics for study in order to understand the nature of quantitative genetic control For example, Drosophila were tested in a fteenchoice maze for geotactic response ( g 1813)The maze was on its side, so at every intersection, a y had to make a choice between going up or going down The ies with the highest scores were chosen as parents for the high line (positive geotaxis; favored downward direction), and the ies with the lowest score were chosen as parents for the low line (negative geotaxis; favored upward direction) The same selection was made for each generation As time progressed, the two lines diverged quite signi cantly.

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Schematics, Diagrams, Circuits, and Given Data: RF = R = 10 k ; R2 = 20 k ;

For most applications, the friction power loss in an aerostatic bearing may be simply ignored as the value is very low However, in applications where the friction power loss must be considered, the power dissipated as heat due to the friction in any full journal bearing is calculated as P =

, 201

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This tells us that there is a large genetic component to the response; the experimenters are successfully amassing more of the downward alleles in the high line and more of the upward alleles in the low line Several other points emerge from this graph First, the high and low responses are slightly different, or asymmetrical The high line responded more quickly, leveled out more quickly, and tended toward the original state more slowly after selection was relaxed (The relaxation of selection occurred when the parents were a random sample of the adults rather than the extremes for geotactic scores) The low line responded more slowly and erratically In addition, the low line returned toward the original state more quickly when selection was relaxed The nature of these responses ( g 1813) indicates that the high line became more homozygous than the low line.

, 404

This is shown by the former s response when selection is relaxed: It has exhausted a good deal of its variability for the polygenes responsible for geotaxis The low line,.

Thus, by connecting each of the three resistors, we can obtain gains 40,000 40,000 40,000 = 500 A2 = 1 + = 200 A3 = 1 + = 100 802 201 404 It is also possible to obtain additional input-stage gains by connecting resistors in parallel: A1 = 1 + 802 201 = 573 404 201 = 1342 (A4 700) (A6 300) 802 404 = 669 (A5 600)

uncertainty introduced by the use of external resistors, since the value of the internally supplied resistors can be controlled more precisely

The McGraw Hill Companies, 2001

151 Use the de nition of the common-mode rejection ratio (CMRR) given in equation 1516 to compute the CMRR (in dB) of the ampli er of Example 151 if RF /R = 100 and A = 10, and if R = 5% of R Assume R = 1 k , RF = 100 k 152 Repeat Exercise 151 for a 1 percent variation in R 153 Repeat Exercise 151 for a 001 percent variation in R 154 Calculate the mismatch in gains for the differential components for the 5 percent

155 Calculate the mismatch in gains for the differential components for the 1 percent resistance mismatch of Exercise 152 156 What value of resistance R1 would permit a gain of 1,000 for the IA of Example 152

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