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Once a cytologic diagnosis of VAIN is made, colposcopic evaluation is recommended. In general, vaginal colposcopy is more dif cult to perform than cervical colposcopy due to the presence of vaginal rugae and abnormal recesses at the cuff after hysterectomy. Colposcopy should be performed using the largest speculum the patient will tolerate followed by application of 4% acetic acid. (Plate 3.1). If the limits of a vaginal lesion cannot be appreciated with the colposcope and 4% acetic acid, then iodine staining (Schiller or Lugol solution) can assist in visualization. Use of Lugol solution allows for visualization of lesions more rapidly than other methods, as lesions appear as nonstaining areas and are more apparent among the vaginal rugae. Lugol solution stains normal squamous cells dark brown as abundant intracellular glycogen will take up iodine. Nonglycogenated cells (including most dysplasic cells with large nuclei and smaller amounts of cytoplasm, non-neoplastic glandular cells, and squamous cells in atrophic mucosa) will not take up iodine and remain light yellow or white, making the lesions to distinguish from the surrounding normal tissue (Plate 16.2). In postmenopausal women, pretreatment with vaginal

The trouble with this notion is that at optimal levels of debt and equity, a company may not have the financial flexibility it needs That is, it may not have quick access to financial reserves (such as cash or debt capacity) to respond to market or economic forces For instance, if a new market opportunity arises, a company needs cash reserves to be able to move into the market before its competitors Similarly, a company may not be able to fund efforts to prevent it from being a takeover target True, the company could issue new equity to raise the funds, but this is risky It dilutes ownership, and unfavorable stock market conditions could force the company to issue equity at a low price relative to value Key point: To maintain financial flexibility, a company must have either excess cash balances or excess debt capacity.

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The trouble here is that too much cash is not good, because it earns below-market returns; excess debt capacity means that the company is not operating at its optimal capital structure Therefore, you might think that having financial flexibility reduces corporate value But this cannot be true, because there must be some value to being able to move fast in response to market conditions so-called strategic financial capability But how can you quantify this value New Model in Action Using the concept of real options, a new model seeks to quantify the value of strategic financial capability The developers, Nancy Beneda, assistant professor of finance at the University of North Dakota, and Theron R Nelson, a finance professor at the same institution, explained their model in great depth in a recent Corporate Finance Review The valuation is done using the Black-Scholes option pricing model.

We turn our attention now to embedding a Python interpreter in a C++ program. We have seen how to call C++ code from Python. Here we aim to do the reverse: call Python code from C++. To do this we use a mix of Python C API routines together with helper types and functions in the Boost.Python library:

The amount that is calculated represents the additional firm value created as a result of the strategic option to invest funds that are available because of increased financial flexibility Put another way, with financial flexibility, a company has the option to invest in future opportunities This option has value To demonstrate, Beneda and Nelson selected a company, Toll Brothers Inc, a major home construction company Companies in this industry are faced with highly volatile investment needs That is why they require the flexibility to be able to fund these needs Using the Black-Scholes model, Beneda and Nelson categorized Toll s strategic financial flexibility as an embedded call option and used these five inputs: 1 Expected investment needs in excess of internal funds for the upcoming year (the strike price) 2.

Present value of expected future cash flows on expected investment needs, in excess of internal funds generated by the firm for the upcoming year (the value of the underlying asset) 3 Volatility of reinvestment needs 4 Risk-free rate of 5% 5 Time frame of one year (to keep the analysis simple).

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