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show anti-HIV activity; however, compounds with Bz at C-6b, 130, 133, and 135, did exhibit anti-HIV activity with EC50 values of 5.9, 0.96, and 0.011 mM. The most potent compound, gomisin G (135), has S-biphenyl con guration and 6b-benzoyl7b-methyl-7a-hydroxy substitutions. In contrast, a 7b-hydroxy substituent (139 and 140) diminished the activity. Compounds 132, 136, 137, and 138 have different substituents on the aromatic rings, but no substituents on C-6. Although these four compounds showed similar EC50 values, 136 and 138, without a methylenedioxy group, showed much lower IC50 values than 132 and 137, which contain one or more methylenedioxy groups on the aromatic rings. These results showed that a C-6b benzoyl group, a C-7b hydroxy substituent, and methylenedioxy substitutions on the aromatic rings are important for enhanced anti-HIV activity.50

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multidrug-resistant P. falciparum in all areas of the world were cured. These drugs derived from the natural A. annua L. have many advantages: quick reduction of fevers, fast clearing parasites in blood (90% of malaria patients recovered within 48 hours), and no signi cant side effects. Although the neurotoxicity was found in animals after high doses of certain compounds, no related clinical toxicity has been observed in humans. Similarly, high doses of artemisinins may induce foetal resorption (no mutagenic or teratogenic) in experimental animals; however, the monitor for hundreds of women in severe malaria or uncomplicated malaria in pregnancy showed artemisinins to be safe for these mothers and babies. 5.6.1.2 Against Other Parasites Many experimental and clinical studies performed in China reveal that artemisinin, artemether, and artesunate are not only the potent antimalarial drugs but also the

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with respect to of the likelihood ratio (x; ( + ), )/ (x; ( ), ), hence the name likelihood ratio method. 35 In a simulation, one would typically sample X by letting X = ( ) + AZ where A is an n n matrix satisfying the Cholesky decomposition, AA = , and Z is a vector of independent standard normal random variables. Substituting this expression in equation (13.84) yields d E [ g(X)] = E[ g( ( ) + AZ)Z A 1 ( )] d (13.85)

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This array consists of each value in the array in range C1:C12, divided into 1. For example, each cell in the original Data range that contains a 200 has a value of 0.5 in the corresponding cell in D1:D12. Summing the range D1:D12 gives the number of unique items in Data. The array formula presented at the beginning of this section essentially creates the array that occupies D1:D12, and sums the values. This formula has a serious limitation: If the range contains any blank cells, it returns an error. The following array formula solves this problem:

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The setup program creates a program subdirectory. By default, this is named c:\mysql. Setup does not create any Start menu items or desktop shortcuts. MySQL is automatically installed as a service under Windows NT, 2000, and XP. By default, this service will start automatically each time the system is rebooted. The service can be controlled through the standard service control panel applet or can be started and stopped using the program winmysql admin.exe. The program can be found in the mysql\bin directory. This utility also makes it easy to change the configuration information for the database running under Windows. MySQL can also be started from the command line. To do this change directory to the MySQL\bin subdirectory, and enter the command:

In Command mode, move the cursor to the line you want to move. Press dd. The specified line disappears into buffer 0 (the default buffer), and the cursor moves to the next line.

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