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Now that we know what the different pieces of our architecture are and what they do, it s time to choose the specific tools we ll use. The tools we have to decide upon are as follows: Web server. This chapter assumes that you either do not need a Web server or that you have chosen the Apache Web server. By virtue of the fact that this book supports the use of open source tools and that the Apache Web server is the most popular Web server in the world today, we assume that if you do need a Web server it will be Apache. Apache is free, open source, and available for most popular operating systems. Servlet container. We will follow the process outlined in 3 in order to decide which servlet engine will be used for the platform. As a reminder, this process goes through four steps:

<JDBCConnectionPool DriverName= com.pointbase.jdbc.jdbcUniversalDriver Name= JWSPool Password= yourchoice Properties= user=public Targets= myserver URL= jdbc:pointbase:server://localhost/demo /> <JDBCTxDataSource JNDIName= JWSPoolDataSource Name= JWSPoolDataSource PoolName= JWSPool Targets= myserver />

Benchmarks can also be customized to re ect the investor s restrictions with respect to particular asset classes, instruments, industries, and the like. Instead of building up a new index from the stock level, we can adjust the return of an index by the contribution to return from certain stocks in the index. For example, a large corporate pension plan might use as its benchmark the return of the S&P 500 index excluding the company s own stock. Or a fund that applies social screens, like excluding tobacco companies, will calculate its index less these stocks.

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Logging Information about ices activity is, by default, sent to the file /var/ log/ices.log. You can change that location (as I changed mine to /home/ chris/myices), the maximum size of the log (2,048KB), or level of log messages (3). You can also set consolelog to 1 (instead of 0) to have log messages go to the console instead of the log file.

TABLE AP8.1-4

The radio object is used to define a radio button in a form. The individual radio button in a group of radio buttons is referenced by the index numbers. For example, the HTML code for defining a group of radio buttons might be as follows:

2

Datagram-oriented instead of circuits. No single point of failure. End-to-end transparency for applications (see below for how this has degraded). End-to-end control. End-to-end security. Complete control by users over the applications and selection of services.

which contains several mutations in RT amino acid residues (M41L, L74V, V106A, and T215Y) and is resistant to AZT, ddI, nevirapine, and other non-nucleoside reverse transcriptase inhibitors (NNRTIs).41 Most previously active DCK derivatives showed dramatically decreased activity or totally lost potency in this new screening system. It is not fully clear why DCK analogs show remarkably reduced activity against the drug-resistant viral strains. Mutations of the viral RT could cause conformational changes directly on the binding sites or other regions that affect binding. Accordingly, DCK might dissociate more rapidly from or not t into the putative mutated target. Therefore, we turned to preparing ring position isomers, a common principle of analog design, as such a change may alter electron distribution in an aromatic ring system or affect the complimentarity toward in vivo receptors.42,43 A series of 30 R, 40 R-di-O-( )-camphanoyl-20 ,20 -dimethyldihydropyrano[2,3f]chromone (DCP, 107) derivatives, which are positional isomers of DCK, were designed and synthesized.42,43 All DCP (107 117) and 30 -acyl-40 -camphanoyl (118 124) derivatives were tested against both the HIV-1IIIB non-drug-resistant strain in H9 lymphocytes and the HIV-1 RTMDR1 multi-RT inhibitor resistant viral strain in MT4 cells (Figure 9-6 and Table 9-6). Because the two screening assays used different protocols, virus strains and cell lines, the activity data cannot be compared between the two different assays. Therefore, our SAR analyses were summarized for each strain.

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