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20 times per second) characteristically reproduces the spasms, and hyperventilation and ischemia increase the tendency Indeed, the Trousseau sign carpal spasms with occlusion of the blood supply to the arm takes advantage of the latter phenomenon That hypocalcemic tetany is attributable to an unstable depolarization of the axonal membrane of the nerve ber is shown by (1) the sensitivity of nerve to percussion (tapping over the facial nerve near its foramen of exit induces a facial twitch, or Chvostek sign), (2) the appearance of fast-frequency doublets and triplets of motor unit potentials in the EMG, (3) evocation of spasm by application of a tourniquet to proximal parts of a limb (causing ischemia of segments of nerve beneath the tourniquet), and (4) the regular association of tingling, prickling paresthesias from excitation of sensory nerve bers Hypocalcemia also causes a lesser change in the muscle bers themselves; hence nerve block does not completely eradicate tetany A condition resembling tetany but without measurable hypocalcemia is the aforementioned benign cramp syndrome (pseudotetany) In the most severe forms, all skeletal muscles are intermittently locked in spasm, and almost any strong postural or voluntary movement leads to cramp When this phenomenon is repeated again and again, the overly active muscles begin to hypertrophy In about half of the authors cases, stimulation of nerve at 15 or more per second produced cramp discharges, as in tetany Biopsies have disclosed no abnormalities of the muscle bers except for a few ringbinden (circumferential bands of myo brils encircling a normal core of longitudinally oriented myo brils) Calcium and diazepam are of no therapeutic value, but some patients respond to phenytoin, quinine, procainamide, or chlorpromazine A familial (autosomal dominant) form of the benign cramp syndrome has been reported by Jusic and coworkers; the cramps affected the distal limb muscles, began in childhood and adolescence, and persisted throughout life Another such family with cramps beginning somewhat later in life and affecting the anterior neck, arm, and abdominal muscles as well as those of the thigh and calf has been described by Ricker and Moxley Also, as mentioned in Chap 50, a familial myalgic-cramp syndrome has been associated with deletion of part of the dystrophin gene (but with little or no dystrophic weakness) A tendency to cramp and pain has also been noted in a number of the congenital myopathies and in some families with Duchenne and Becker dystrophies Satoyoshi Syndrome Satoyoshi has described a group of patients who, in addition to widespread severe cramping of muscle, showed universal alopecia, amenorrhea, intestinal malabsorption, and sometimes epiphyseal destruction and retarded growth Most Japanese patients described by Satoyoshi were under 20 years old, but the cases we have observed have been older The serum calcium in these patients is normal, and the EMG shows only highfrequency discharges that are characteristic of cramps A male patient of ours with this condition had decades of chronic diarrhea, alopecia, and continuous and extremely painful calf cramps that looked, from the surface, like fasciculations This triad virtually identi es the disease The cause of the disorder is entirely obscure but tentatively presumed to be autoimmune Glucocorticoids, particularly in high doses over short periods, have been tried with some success; dantrolene has also been used, and we had the impression that plasma exchange may have been helpful in one case.

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4 Sep 2017 ... If I want to display a PDF file in the browser instead of downloading a copy, I can tell the browser via an additional Content-Disposition ...

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Syncfusion PDF viewer for ASP . NET MVC is a lightweight HTML5 component that can be used for viewing, reviewing, and printing PDF documents within web  ...

FIGURE 1-5

States of Persistent Fasciculation, Myokymia, Continuous Muscle Fiber Activity, Neuromyotonia, Stiff-Man Syndrome, and Schwartz-Jampel Syndrome

This is a confusing group of clinical states, all characterized by some degree of regional continuous muscular activity, that in some cases cannot be fully differentiated from one another From a clinical perspective we have found it is useful to categorize them in groups that are caused by (1) hyperexcitability of the peripheral motor nerves, (2) centrally mediated hyperexcitability of motor output, (3) nonmyotonic hyperexcitability of muscle, and (4) disorders of extracellular matrix proteins that alter muscle membrane excitability

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Q567731 - ASP.NET PDF viewer control | DevExpress Support Center
Feb 3, 2014 · Technology: .NET, Platform: ASP.NET MVC, Type: Question, Subject: ASP.NET PDF viewer control.

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Jun 6, 2015 · Here Mudassar Ahmed Khan has explained how to open (view) PDF Files on Browser in ASP.Net using C# and VB.Net. This article will explain ...

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