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gastrointestinal disease and are often tolerated poorly by the elderly 3 Levodopa Levodopa, which is converted in the body to dopamine, improves all of the major features of parkinsonism, including bradykinesia, but does not stop progression of the disorder The most common early side effects of levodopa are nausea, vomiting, and hypotension, but cardiac arrhythmias may also occur Dyskinesias, restlessness, confusion, and other behavioral changes tend to occur somewhat later and become more common with time Levodopainduced dyskinesias may take any conceivable form, including chorea, athetosis, dystonia, tremor, tics, and myoclonus An even later complication is the on-off phenomenon, in which abrupt but transient fluctuations in the severity of parkinsonism occur unpredictably but frequently during the day The off period of marked bradykinesia has been shown to relate in some instances to falling plasma levels of levodopa During the on phase, dyskinesias are often conspicuous but mobility is increased Carbidopa, which inhibits the enzyme responsible for the breakdown of levodopa to dopamine, does not cross the blood-brain barrier When levodopa is given in combination with carbidopa, the extracerebral breakdown of levodopa is diminished This reduces the amount of levodopa required daily for beneficial effects, and it lowers the incidence of nausea, vomiting, hypotension, and cardiac irregularities Such a combination does not prevent the development of the on-off phenomenon, and the incidence of other side effects (dyskinesias or psychiatric complications) may actually be increased Sinemet, a commercially available preparation that contains carbidopa and levodopa in a fixed ratio (1:10 or 1:4), is generally used Treatment is started with a small dose eg, one tablet of Sinemet 25/100 (containing 25 mg of carbidopa and 100 mg of levodopa) three times daily and gradually increased depending on the response Sinemet CR is a controlled-release formulation (containing 25 or 50 mg of carbidopa and 100 or 200 mg of levodopa) It is sometimes helpful in reducing fluctuations in clinical response to treatment and in reducing the frequency with which medication must be taken The commercially available combination of levodopa with both carbidopa and entacapone (Stalevo) may also be helpful in this context and is discussed in the following section on COMT inhibitors Response fluctuations are also reduced by keeping the daily intake of protein at the recommended minimum and taking the main protein meal as the last meal of the day The dyskinesias and behavioral side effects of levodopa are dose-related, but reduction in dose may eliminate any therapeutic benefit Levodopa-induced dyskinesias may also respond to amantadine Levodopa therapy is contraindicated in patients with psychotic illness or narrow-angle glaucoma It should not be given to patients taking monoamine oxidase A inhibitors or within 2 weeks of their withdrawal, because hypertensive crises may result Levodopa should be used with care in patients with suspected malignant melanomas or with active peptic ulcers because of concerns that it may exacerbate these disorders.

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Solution to Exercise 20-2. We ll try something slightly more complicated now. Write a program to display the name and ID of products with fewer than 10 units in stock. This is another rather simple exercise, again focusing on the command string. This time, you need to include a where clause in your string. From the Products table, you want to retrieve the ProductID and ProductName columns, if the UnitsInStock column is less than 10. Note that you don t actually retrieve the UnitsInStock column; you only use it to determine which records to retrieve. The command string looks like this:

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Treatment usually consists of replacement of fluids and electrolytes and, very rarely, management of hypovolemic shock and respiratory compromise In mild diarrhea, increasing ingestion of juices and clear soups is adequate In more severe cases of dehydration (postural lightheadedness, decreased urination), oral glucose-based rehydration solutions can be used (Ceralyte, Pedialyte) In general, most cases of acute gastroenteritis are self-limited and do not require therapy other than supportive measures When symptoms persist beyond 3 4 days, initial presentation is accompanied by fever or bloody diarrhea, or if the patient is immunocompromised, cultures of stool are usually obtained Symptoms have often resolved by the time cultures are completed In this case, even if a pathogen is isolated, therapy is not needed (except for Shigella, since the infecting dose is so small that therapy to eradicate organisms from the stool is indicated for epidemiologic reasons) If symptoms persist and a pathogen is isolated, it is reasonable to institute specific treatment even though therapy has not been conclusively shown to alter the natural history of disease for most pathogens Exceptions include infection with Shigella where antibiotic therapy has been shown to shorten the duration of symptoms by 2 3 days, infections with E coli O157:H7 (antibiotic therapy does not ameliorate symptoms and may increase the risk of developing hemolytic-uremic syndrome), and Campylobacter infections (early therapy, within 4 days of onset of symptoms, shortens the course of disease) Uncomplicated gastroenteritis due to Salmonella does not require therapy because the disease is usually self-limited and therapy may prolong carriage and perhaps increase relapses Because bacteremia with complications can occur in high-risk patients, some experts have recommended therapy for Salmonella in patients over the age of 50, in organ transplant recipients, in those with HIV, in patients taking corticosteroids, in those with lymphoproliferative diseases, and in those with vascular grafts Ciprofloxacin, 500 mg every 12 hours for 5 days, is effective in shortening the course of illness compared with placebo in patients presenting with diarrhea, whether a pathogen is isolated or not However, because of concerns about selecting for resistant organisms (especially Campylobacter, where increasing resistance to fluoroquinolones has been documented and erythromycin is the drug of choice) coupled with the fact that most infectious diarrhea is self-limited, routine use of antibiotics for all patients with diarrhea is not recommended Antibiotics.

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