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If psoriasis involves more than 30% of the body surface, it is difficult to treat with topical agents The treatment of choice is outpatient UVB light exposure three times weekly Clearing occurs in an average of 7 weeks, but maintenance may be required Severe psoriasis unresponsive to outpatient ultraviolet light may be treated in a psoriasis day care center with the Goeckerman regimen, which involves use of crude coal tar for many hours and exposure to UVB light Such treatment may offer the best chance for prolonged remissions PUVA may be effective even in patients who have not responded to standard UVB treatment Long-term use of PUVA is associated with an increased risk of skin cancer (especially squamous cell carcinoma and perhaps melanoma), particularly in persons with fair complexions Thus, periodic examination of the skin is imperative Atypical lentigines are a common complication There can be rapid aging of the skin in fair individuals Cataracts have not been reported with proper use of protective glasses PUVA may be used in combination with other therapy, such as acitretin or methotrexate Parenteral corticosteroids should not be used because of the possibility of induction of pustular lesions Methotrexate is very effective for severe psoriasis in doses up to 25 mg once weekly It should be used according to published protocols Liver biopsy is performed initially after methotrexate has been used long enough by the patient to demonstrate that it is effective and well tolerated, and then at intervals depending on the cumulative dose, usually 15 2 g Administration of folic acid, 1 2 mg daily, will eliminate nausea caused by methotrexate without compromising efficacy Acitretin, a synthetic retinoid, is most effective for pustular psoriasis in dosages of 05 075 mg/kg/d, but it also improves erythrodermic and plaque types and psoriatic arthritis Liver enzymes and serum lipids must be checked periodically Because acitretin is a teratogen and persists for long periods in fat, women of childbearing age must wait at least 3 years after completing acitretin treatment before considering pregnancy When used as single agents, retinoids will flatten psoriatic plaques, but will rarely result in complete clearing Retinoids find their greatest use when combined with phototherapy either UVB or PUVA, with which they are synergistic Cyclosporine dramatically improves psoriasis and may be used to control severe cases Rapid relapse (rebound) is the rule after cessation of therapy, so another agent must be added if cyclosporine is stopped Systemic immunomodulators can be effective in treating psoriasis The tumor necrosis factor (TNF) inhibitors etanercept (Enbrel), 50 mg twice weekly, infliximab (Remicade), and adalimumab (Humira) have shown antipsoriatic activity Infliximab provides the most rapid response and can be used for severe pustular or.

You can also change the value of a variable later in the program. That is why they re called variables; their values can vary, and that s what makes them useful.

You can use and modify this code in other scripts to make sure that users are running the correct version of AppleScript. The only change I made was to move the code to a subroutine and pass in the expected program version. The next section of code prompts the user, asking if it should delete all playlists. This code is a good example of a reoccurring theme in AppleScript programming prompting the user for information and using control statements to perform the correct action:

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Peripheral neuropathies can be categorized on the basis of the structure primarily affected The predominant pathologic feature may be axonal degeneration (axonal or neuronal neuropathies) or paranodal or segmental demyelination The distinction may be possible on the basis of neurophysiologic findings Motor and sensory conduction velocity can be measured in accessible segments of peripheral nerves In axonal neuropathies, conduction velocity is normal or reduced only mildly and needle electromyography provides evidence of denervation in affected muscles In demyelinating neuropathies, conduction may be slowed considerably in affected fibers, and in more severe cases, conduction is blocked completely, without accompanying electromyographic signs of denervation Nerves may be injured or compressed by neighboring anatomic structures at any point along their course Common mononeuropathies of this sort are considered below They lead to a sensory, motor, or mixed deficit that is restricted to the territory of the affected nerve A similar clinical disturbance is produced by peripheral nerve tumors, but these are rare except in patients with Recklinghausen s disease Multiple mononeuropathies suggest a patchy multifocal disease process such as vasculopathy (eg, diabetes, arteritis), an infiltrative process (eg, leprosy, sarcoidosis), radiation damage, or an immunologic disorder (eg, brachial plexopathy) Diffuse polyneuropathies lead to a symmetric sensory, motor, or mixed deficit, often most marked distally They include the hereditary, metabolic, and toxic disorders; idiopathic inflammatory polyneuropathy (Guillain-Barr syndrome); and the peripheral neuropathies that may occur as a nonmetastatic complication of malignant diseases Involvement of motor fibers leads to flaccid weakness that is most marked distally; dysfunction of sensory fibers causes impaired sensory perception Tendon reflexes are depressed or absent Paresthesias, pain, and muscle tenderness may also occur

Riluzole, 50 mg orally twice daily, which reduces the presynaptic release of glutamate, may slow progression of amyotrophic lateral sclerosis There is otherwise no specific treatment except in patients with gammopathy, in whom plasmapheresis and immunosuppression may lead to improvement Therapeutic trials of various neurotrophic factors to slow disease progression have yielded generally disappointing results as have trials of celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, and pentoxifylline Symptomatic and supportive measures may include prescription of anticholinergic drugs (such as trihexyphenidyl, amitriptyline, or atropine) or use of a portable suction machine if drooling is troublesome, braces or a walker to improve mobility, and physical therapy to prevent contractures Behavioral modification (eg, exercising facial muscles and encouraging frequent swallowing) or over-the-counter decongestants may also help mild drooling Spasticity may be helped by baclofen or diazepam A semiliquid diet or nasogastric tube feeding may be needed if dysphagia is severe Gastrostomy or cricopharyngomyotomy is sometimes resorted to in extreme cases of predominant bulbar involvement, and tracheostomy may be necessary if respiratory muscles are severely affected; however, in the terminal stages of these disorders, the aim of treatment should be to keep patients as comfortable as possible Information on palliative care is provided in 5

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int myVariable; // some other code here myVariable = 15; // assign 15 to myVariable // some other code here myVariable = 12; // now it is 12

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