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Motor tics are the initial manifestation in 80% of cases and most commonly involve the face, whereas in the remaining 20%, the initial symptoms are phonic tics; ultimately a combination of different motor and phonic tics develop in all patients These are noted first in childhood, generally between the ages of 2 and 15 Motor tics occur especially about the face, head, and shoulders (eg, sniffing, blinking, frowning, shoulder shrugging, head thrusting, etc) Phonic tics commonly consist of grunts, barks, hisses, throat-clearing, coughs, etc, but sometimes also of verbal utterances including coprolalia (obscene speech) There may also be echolalia (repetition of the speech of others), echopraxia (imitation of others movements), and palilalia (repetition of words or phrases) Some tics may be self-mutilating in nature, such as nail-biting, hair-pulling, or biting of the lips or tongue The disorder is chronic, but the course may be punctuated by relapses and remissions Obsessive-compulsive behaviors are commonly associated and may be more disabling than the tics themselves A family history is sometimes obtained and inheritance has been attributed to an autosomal dominant gene with variable penetrance In some instances, mutations in the SLITRK1 gene on chromosome 13q have been incriminated Examination usually reveals no abnormalities other than the tics In addition to obsessive-compulsive behavior disorders, psychiatric disturbances may occur because of the associated cosmetic and social embarrassment Electroencephalography may show minor nonspecific abnormalities of no diagnostic relevance The diagnosis of the disorder is often delayed for years, the tics being interpreted as psychiatric illness or some other form of abnormal movement Patients are thus often subjected to unnecessary treatment before the disorder is recognized The tic-like character of the abnormal movements and the absence of other neurologic signs should differentiate this disorder from other movement disorders presenting in childhood Wilson s disease, however, can simulate the condition and should be excluded.

If you are anything like me, you own lots of CDs, MP3s, and even LPs. With the advent of iTunes and cheap, large hard drives, I have taken to converting many of my CDs to MP3 format and storing then on my hard disk. Doing so makes it easy to transport music from my desktop machine to my laptop or iPod, or to burn mixes of MP3s to CD. The problem is, as my music collection expands, it s difficult to keep track of what I have and where it is located. The iTunes program solves some of this situation through playlists lists of related songs that help you organize related songs in your music collection under a name. However, you need to create each playlist by hand. (The current [as of this writing] version of iTunes has a feature called Smart Playlists, which automates the creation of custom playlists.)

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Phenothiazines and butyrophenones may produce a wide variety of abnormal movements, including parkinsonism, akathisia (ie, motor restlessness), acute dystonia, chorea, and tardive dyskinesia These complications are discussed in 25 Chorea may also develop in patients receiving levodopa, bromocriptine, anticholinergic drugs, phenytoin, carbamazepine, lithium, amphetamines, or oral contraceptives, and it resolves with withdrawal of the offending substance Similarly, dystonia may be produced by levodopa, bromocriptine, lithium, metoclopramide, or carbamazepine; and parkinsonism by reserpine, tetrabenazine, and metoclopramide Postural tremor may occur with a variety of drugs, including epinephrine, isoproterenol, theophylline, caffeine, lithium, thyroid hormone, tricyclic antidepressants, and valproic acid

namespace Exercise_20_3 { class Program { static void Main(string[] args) { // create the data connection string connectionString = "server=.\\sqlexpress; " + "Trusted_Connection=yes;database=Northwind"; // create the string to hold the SQL command // to get records from the Customers table string commandString = "select e.FirstName, e.LastName " + "from Employees e "+ "join EmployeeTerritories et on " + "e.EmployeeID = et.EmployeeID " + "join Territories t on et.TerritoryID = " + "t.TerritoryID "+ "join Region r on t.RegionID = " + "r.RegionID " + "where r.RegionID = 1"; // create the data adapter with the // connection string and command SqlDataAdapter myDataAdapter = new SqlDataAdapter(commandString, connectionString); // Create and fill the DataSet object DataSet myDataSet = new DataSet( ); myDataAdapter.Fill(myDataSet); // Retrieve the Orders table DataTable myDataTable = myDataSet.Tables[0]; // iterate over the rows collection // and output the fields Console.WriteLine("Employees in Region 1:"); foreach (DataRow dataRow in myDataTable.Rows) { Console.WriteLine("{0} {1}", dataRow["FirstName"], dataRow["LastName"]); } }

This disorder may occur as a primary (idiopathic) disorder or in relation to pregnancy, iron-deficiency anemia, peripheral neuropathy, or periodic leg movements of sleep It may have a hereditary basis Restlessness and curious sensory disturbances lead to an irresistible urge to move the limbs, especially during periods of relaxation Disturbed nocturnal sleep and excessive daytime somnolences may result Therapy is with nonergot dopamine agonists, such as pramipexole (0125 05 mg once daily or ropinirole (025 40 mg once daily) 2 to 3 hours before bedtime, or with benzodiazepines, such as clonazepam Levodopa is also helpful but may lead to an augmentation of symptoms, so that its use is generally reserved for those who fail other measures In some instances, opiates are required to control symptoms

Bogan RK et al Ropinirole in the treatment of patients with restless legs syndrome: a US-based randomized, double-blind, placebo-controlled clinical trial Mayo Clin Proc 2006 Jan;81 (1):17 27 [PMID: 16438474]

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