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consider it so: One of the reasons Southwest is so successful is because they promise something very simple and they deliver that very consistently, he said at a conference in 2004 I think that s a better paradigm than where we ve been historically and where we need to move to Also consider the cases of two other airlines: British Airways and Continental British Airways CEO Rod Eddington in 2002 declared that our whole business is too complicated The airline was losing out to low-fare carriers, he said, because of too much complexity complexity in pricing, in operations, in the supply chain, in IT Continental had reached the same conclusion in the nineties and had embarked on a similar tack Said Continental CEO Gordon Bethune4: The point is, you d better figure out what your customers the customers you want value Because that s what they ll buy Anything else is a waste of their money, and they ll figure that out in a hurry Continental deliberately reduced the number of aircraft types to five and got rid of several Airbus models that could never earn their cost of capital on Continental routes

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The exact mechanisms of sebum production have not been elucidated but the influential factors are thought to be multifactorial Retinoids, hormones, and growth factors affect SG activity and differentiation Androgens have long been thought to play a role in this process because sebum secretion increases when puberty begins and women with polycystic ovarian disease exhibit acne Acne breakouts tend to occur right before a woman s menstrual cycle and a recent study showed that menstruation is accompanied by dilatation of the pilosebaceous ducts reaching its maximum during ovulation and exhibiting the maximum amount of sebum secretion8 However, the exact role of hormones in acne is confusing as studies are conflicting Testosterone is not thought to be directly related to sebum secretion because although men have much higher levels of testosterone than women do, their sebum secretion rates are only slightly higher47 The weak androgen dihydroepiandrosterone sulfate (DHEAS) may play a role in acne DHEAS is converted to testosterone by several enzymes that are found in the SGs, including type 1 5- -reductase However, a type 1 5- -reductase inhibitor was not found to be effective in the treatment of acne48 Estrogens, insulin, glucocorticoids, and prolactin are also thought to influence SG function, but the mecha-

ity to detect them, and formulate an action plan for the highest priority risks A key (and usual) outcome of risk analysis is the requirement for a stakeholder analysis In the event of a product deletion, or a change in the business or site closure, further planning around this is required Another major source of risk is disruption to customers, requiring a Business Continuity Plan, ie, a detailed plan for migrating processes, customers, etc

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