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The original version of SQL was developed as the query language for IBM s System R project, and its early development can be traced in [90, 130] SQL has since become the most widely used relational query language, and its development is now subject to an international standardization process A very readable and comprehensive treatment of SQL-92 is presented by Melton and Simon in [455]; we refer readers to this book and to [170] for a more detailed treatment Date o ers an insightful critique of SQL in [167] Although some of the problems have been addressed in SQL-92, others remain A formal semantics for a large subset of SQL queries is presented in [489] SQL-92 is the current International Standards Organization (ISO) and American National Standards Institute (ANSI) standard Melton is the editor of the ANSI document on the SQL-92 standard, document X3135-1992 The corresponding ISO document is ISO/IEC 9075:1992 A successor, called SQL:1999, builds on SQL-92 and includes procedural language extensions, user-de ned types, row ids, a call-level interface, multimedia data types, recursive queries, and other enhancements; SQL:1999 is close to rati cation (as of June 1999) Drafts of the SQL:1999 (previously called SQL3) deliberations are available at the following URL: ftp://jerryeceumassdedu/isowg3/ The SQL:1999 standard is discussed in [200] Information on ODBC can be found on Microsoft s web page (wwwmicrosoftcom/data/odbc), and information on JDBC can be found on the JavaSoft web page (javasuncom/products/jdbc) There exist many books on ODBC, for example, Sander s ODBC Developer s Guide [567] and the Microsoft ODBC SDK [463] Books on JDBC include works by Hamilton et al [304], Reese [541], and White et al [678] [679] contains a collection of papers that cover the active database eld [695] includes a good in-depth introduction to active rules, covering semantics, applications and design issues [213] discusses SQL extensions for specifying integrity constraint checks through triggers [104] also discusses a procedural mechanism, called an alerter, for monitoring a database [154] is a recent paper that suggests how triggers might be incorporated into SQL extensions In uential active database prototypes include Ariel [309], HiPAC [448], ODE [14], Postgres [632], RDL [601], and Sentinel [29] [126] compares various architectures for active database systems [28] considers conditions under which a collection of active rules has the same behavior, independent of evaluation order Semantics of active databases is also studied in [244] and [693] Designing and managing complex rule systems is discussed in [50, 190] [121] discusses rule management using Chimera, a data model and language for active database systems.

The most potent pharmacologic inhibitor of sebum secretion is the retinoid isotretinoin (13-cis retinoic acid) Reductions in sebum excretion rates can be reduced by 90% as early as 2 weeks after initiating treatment with isotretinoin Its exact mechanism of action has not been fully described or understood yet, but histologically it shrinks the SG size and the sebocytes lose their characteristic interior accumulation of lipids2,84 Hypothesized mechanisms of action of 13-cis retinoic acid in reducing sebum are listed in Table 10-6

Family A has slipped in competitive position over the last year in what is only a moderately profitable market This indicates an area of concern unless action is taken

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Family B has not lost ground against competitors in terms of relative EP although it did see , a drop in some volume It still has a weak competitive position However the overall market profitability seems to be eroding Family C represents the only good news The market profitability is high and EGI is continuing to improve its relative competitive position However, there has been no revenue growth over the past year A focus on growing the high-EP Family C would drive up shareholder returns They have now also completed a Complexity Matrix (see Figure 812)

Many patients self-report seasonal variability in self-perceived oily skin Strauss et al suggested that there is no evidence for seasonal changes in SG activity, although the skin may appear oilier in hot weather because of changes in the viscosity of SSLs, making the skin feel oilier19 In addition, sebum excretion rates have been shown to be increased with exposure to higher temperatures; however, this measure may reflect a change in sebum collection methods (increased uptake of sebum on collection paper) used to measure sebum production rather than an actual increase in sebum production 75 In 2005, Youn et al observed regional and seasonal variations in sebum secretion that led to changes of skin type from dry to oily, resulting in what they termed a combination skin type 65 This was the first study to show sebum changes throughout different seasons Forty-six patients were included in the study and their sebum secretion was measured over an entire year They reported that summer was the only season in which a significant increase in sebum secretion was seen In addition, a reduction in the dry skin type and an increase in the oily type based on their categorization system was recorded in the summer

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Family AContractor 5-7, Residential Family BContractor 8-10, Recreational 8-10 Family CRecreational 5-7

In a 2006 study, chemical peels using 30% glycolic acid solution and Jessner s solution were not shown to decrease TABLE 10-6 Hypothesized Mechanisms by Which Isotretinoin Suppresses Sebum Affect on the cell cycle progression, differentiation, cell survival, and apoptosis by inhibiting G1/S phase of cell cycle and inhibiting DNA synthesis84 Inhibition of 3-alpha-hydroxysteroid activity of retinol dehydrogenase leading to decreased steroid in vivo synthesis2 It may act in a receptor-independent manner, in uencing cellular signaling pathways by either direct protein interactions, as demonstrated with other retinoids, or by enzyme inhibition85

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