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The integrating ADC operates by charging and discharging a capacitor, according to the following principle: if one can ensure that the capacitor charges (discharges) linearly, then the time it will take for the capacitor to discharge is linearly related to the amplitude of the voltage that has charged the capacitor In practice, to limit the time it takes to perform a conversion, the capacitor is not required to charge fully Rather, a clock is used to allow the input (analog) voltage to charge the capacitor for a short period of time, determined by a xed number of clock pulses Then the capacitor is allowed to discharge through a known circuit, and the corresponding clock count is incremented until the capacitor is fully discharged The latter condition is veri ed by a comparator, as shown in Figure 1528 The clock count accumulated during the discharge time is proportional to the analog voltage

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In the gure, the switch causes the counter to reset when it is connected to the reference voltage, Vref The reference voltage is used to provide a known, linear discharge characteristic through the capacitor (see the material on the opamp integrator in 12) When the comparator detects that the output of the integrator is equal to zero, it switches state and disables the NAND gate, thus stopping the count The binary counter output is now the digital counterpart of the voltage va Other common types of ADC are the so-called successive-approximation ADC and the ash ADC

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Even when an extremely large number of gametes is produced in each generation, each successive generation is the result of a sampling of a relatively small portion of the gametes of the previous generation. A sample may not be an accurate representation of a population, especially if the sample is small. Thus, the second assumption of the Hardy-Weinberg equilibrium is that the population is in nitely large. A large population produces a large sample of successful gametes. The larger the sample, the greater the probability that the allelic frequencies of the offspring will accurately represent the allelic frequencies in the parental population. When populations are small or when alleles are rare, changes in allelic frequencies take place due to chance alone. These changes are referred to as random genetic drift, or just genetic drift.

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The ash ADC is fully parallel and is used for high-speed conversion A resistive divider network of 2n resistors divides the known voltage range into that many equal increments A network of 2n 1 comparators then compares the unknown voltage with that array of test voltages All comparators with inputs exceeding the unknown are on ; all others are off This comparator code can be converted to conventional binary by a digital priority encoder circuit For example, assume that the three-bit ash ADC of Figure 1529 is set up with Vref = 8 V An input of 62 V is provided If we number the comparators from the top of Figure 1529, the state of each of the seven comparators is as given in Table 154

relatively small population can still closely approximate Hardy-Weinberg equilibrium. In other words, minor deviations from the other assumptions can still result in a good t to the equilibrium; only major deviations can be detected statistically. Second, the Hardy-Weinberg equilibrium is extremely resilient to change because, regardless of the perturbation, the equilibrium is usually reestablished after only one generation of random mating. The new equilibrium will be, however, at the new allelic frequencies the Hardy-Weinberg equilibrium does not return to previous allelic values.

Table 154 State of comparators in a 3-bit ash ADC Input on + line 7V 6V 5V 4V 3V 2V 1V Input on line 62 V 62 V 62 V 62 V 62 V 62 V 62 V

Known Quantities: ADC resolution Find: Number of comparators required Analysis: The number of comparators needed is 2n 1 = 15 Comments: The ash ADC has the advantage of high speed because it can

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