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In 1909, W. Johannsen, who studied seed weight in the dwarf bean plant (Phaseolus vulgaris), demonstrated that polygenic traits are controlled by many genes. The parent population was made up of seeds (beans) with a continuous distribution of weights. Johannsen divided this parental group into classes according to weight, planted them, self-fertilized the plants that grew, and weighed the F1 beans. He found that the parents with the heaviest beans produced the progeny with the heaviest beans, and the parents with the lightest beans produced the progeny with the lightest beans (table 18.4). There was a signi cant correlation coef cient between parent and progeny bean weight (r 0.34 0.01). He continued this work by beginning nineteen lines (populations) with beans from various points on the original distribution and sel ng each successive generation for the next several years. After a few generations, the means and variances stabilized within each line. That is, when Johannsen chose, within each line, parent plants with heavier-than-average or lighter-than-average seeds, the offspring had the parental mean with the parental variance for seed size. For example, in one line, plants with both the lightest average bean weights (24 centigrams) and plants with the heaviest average bean weights (47 cg) produced offspring with average bean weights of 37 cg. By sel ng the plants each generation, Johannsen had made them more and more homozygous, thus lowering the number of segregating polygenes. Therefore, the lines became homozygous for certain of the polygenes (different in each line), and any variation in bean weight was then caused only by the environment. Johannsen thus showed that quantitative traits were under the control of many segregating loci.

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(157)

Applying KCL at the inverting node (under the usual assumption that the input current going into the op-amp is negligible), we set iF = iS and obtain the expression vout va = RF RF + R + = 1+ RF R R vb RF va + R R RF + R + R vb R R

The McGraw Hill Companies, 2001

so that the output voltage may be computed to be vout = RF R + RF R va RF + R + R RF v R b (158)

the center of the cell and seems to be involved in the formation of a constricting ring in animal cells or in the growth of a cell plate in plant cells. The cell has now entered the G1 phase of the cell cycle (see g. 3.6). Figure 3.18 summarizes mitosis.

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Note that if the term R in the denominator were zero, the same result would be obtained as in Example 124: vout = (RF /R)(va vb ); however, because of the resistor mismatch, there is a corresponding mismatch between the gains for the two differential signal components Further and more important if the original signals, va and vb , contained both differential-mode and common-mode components: va = va dif + vcom such that va = A(va dif + vcom ) vb = A(vb dif + vcom ) (1510) vb = vb dif + vcom (159)

then the common-mode components would not cancel out in the output of the ampli er, because of the gain mismatch, and the output of the ampli er would be given by vout = RF R + RF R A(va dif + vcom ) RF A(vb dif + vcom ) RF + R + R R (1511)

life functions; with mitosis, they will produce offspring cells with these same capabilities. With this stability assured, single-celled organisms could thrive and multicellular organisms could evolve.

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